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Article

Simian virus 40 large T overcomes p300 repression of c-Myc.

Virology - 1 Aug 2008

Singhal Ghata, Kadeppagari Ravi Kumar, Sankar Natesan, Thimmapaya Bayar

Abstract excerpt

We previously showed that in quiescent cells p300/CBP negatively regulates the cell cycle G1-S transition by keeping c-Myc in a repressed state and that adenovirus E1A induces c-Myc by binding to p300/CBP. Studies have shown that p300/CBP binding to simian virus 40 large T is indirect and mediated by p53. By using a series of large T mutants that fail to bind to various cellular proteins including p53 as well as...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18570961
DOI: 10.1016/j.virol.2008.04.042
PMCID: PMC2519027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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