Article
Prophylactic laparoscopic gastrectomy for hereditary diffuse gastric cancer: a case series in a single family.
JSLS : Journal of the Society of Laparoendoscopic Surgeons - 1 Jan 2000
Hackenson David, Edelman David A, McGuire Tim, Weaver Donald W, Webber John D
Abstract excerpt
BACKGROUND: Hereditary diffuse gastric carcinomas (HDGCs) are particularly troubling because of autosomal dominant heritance, high penetrance, early age of onset, and a lack of effective treatment once symptomatic. HDGC is further complicated by difficulty of effective screening. Gastrectomy provides definitive treatment for CDH1 mutation-positive patients. Attempting to minimize the morbidity and mortality of...
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