Article
HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells.
Nature neuroscience - 1 Apr 2011
Jacob Claire, Christen Carlos N, Pereira Jorge A, Somandin Christian, Baggiolini Arianna, Lötscher Pirmin, Ozçelik Murat, Tricaud Nicolas, Meijer Dies, Yamaguchi Teppei, Matthias Patrick, Suter Ueli
Abstract excerpt
Histone deacetylases (HDACs) are major epigenetic regulators. We show that HDAC1 and HDAC2 functions are critical for myelination of the peripheral nervous system. Using mouse genetics, we have ablated Hdac1 and Hdac2 specifically in Schwann cells, resulting in massive Schwann cell loss and virtual absence of myelin in mutant sciatic nerves. Expression of Sox10 and Krox20, the main transcriptional regulators of...
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