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Article

Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages.

Development (Cambridge, England) - 1 Sept 2007

Schreiner Silke, Cossais François, Fischer Kerstin, Scholz Stefanie, Bösl Michael R, Holtmann Bettina, Sendtner Michael, Wegner Michael

Abstract excerpt

The transcription factor Sox10 regulates early neural crest development, specification of neural crest-derived lineages and terminal differentiation of oligodendrocytes in the central nervous system. Here, we generated two novel hypomorphic Sox10 alleles in the mouse. Mutant mice either expressed a Sox10 protein with a triple alanine substitution in the dimerization domain, or a Sox10 protein with a deletion in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17699610
DOI: 10.1242/dev.003350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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