Article
Krox-20 controls myelination in the peripheral nervous system.
Nature - 27 Oct 1994
Topilko P, Schneider-Maunoury S, Levi G, Baron-Van Evercooren A, Chennoufi A B, Seitanidou T, Babinet C, Charnay P
Abstract excerpt
The molecular mechanisms controlling the process of myelination by Schwann cells remain elusive, despite recent progress in the identification and characterization of genes encoding myelin components (reviewed in ref. 1). We have created a null allele in the mouse Krox-20 gene, which encodes a zinc-finger transcription factor, by in-frame insertion of the Escherichia coli lacZ gene, and have shown that hindbrain...
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