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Article

Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells.

Brain : a journal of neurology - 1 Feb 2013

Doddrell Robin D S, Dun Xin-Peng, Shivane Aditya, Feltri M Laura, Wrabetz Lawrence, Wegner Michael, Sock Elisabeth, Hanemann C Oliver, Parkinson David B

Abstract excerpt

Loss of the Merlin tumour suppressor causes abnormal de-differentiation and proliferation of Schwann cells and formation of schwannoma tumours in patients with neurofibromatosis type 2. Within the mature peripheral nerve the normal development, differentiation and maintenance of myelinating and non-myelinating Schwann cells is regulated by a network of transcription factors that include SOX10, OCT6 (now known as...

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Source

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Identifiers

PMID: 23413263
DOI: 10.1093/brain/aws353
PMCID: PMC3572932

Genes

SOX10
NFATC4
PDGFRB
MPZ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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