Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

<i>Sox10</i> is required for Schwann‐cell homeostasis and myelin maintenance in the adult peripheral nerve

12 Apr 2011

Abstract excerpt

The transcription factor Sox10 functions during multiple consecutive stages of Schwann-cell development in the peripheral nervous system (PNS). Although Sox10 continues to be expressed in mature Schwann cells of the adult peripheral nerve, it is currently unclear whether it is still functional. Here, we used a genetic strategy to selectively delete Sox10 in glia of adult mice in a tamoxifen-dependent manner. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hair Growth and Disorders
Share to Hereditary Neurological Disorders
Share to Nerve injury and regeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21491499
DOI: 10.1002/glia.21173

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

<i>Sox10</i> is required for Schwann‐cell homeostasis and myelin maintenance in the adult peripheral nervePMID 21491499Read ↗

Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage.Semantic proximity Read ↗

Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10.Semantic proximity Read ↗

Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages.Semantic proximity Read ↗

HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells.Semantic proximity Read ↗

Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells.Semantic proximity Read ↗

Sox4 participates in the modulation of Schwann cell myelination.Semantic proximity Read ↗

Myelin deficiencies in both the central and the peripheral nervous systems associated with a SOX10 mutation.Semantic proximity Read ↗

The biology and pathobiology of Schwann cells.Semantic proximity Read ↗

Tead1 regulates the expression of Peripheral Myelin Protein 22 during Schwann cell development.Semantic proximity Read ↗

Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs.Semantic proximity Read ↗

SOX10: 20 years of phenotypic plurality and current understanding of its developmental function.Semantic proximity Read ↗

The Neurobiology of Schwann CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.