Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction.

Nature neuroscience - 1 Jul 2009

Ye Feng, Chen Ying, Hoang ThaoNguyen, Montgomery Rusty L, Zhao Xian-hui, Bu Hong, Hu Tom, Taketo Makoto M, van Es Johan H, Clevers Hans, Hsieh Jenny, Bassel-Duby Rhonda, Olson Eric N, Lu Q Richard

Abstract excerpt

Oligodendrocyte development is regulated by the interaction of repressors and activators in a complex transcriptional network. We found that two histone-modifying enzymes, HDAC1 and HDAC2, were required for oligodendrocyte formation. Genetic deletion of both Hdac1 and Hdac2 in oligodendrocyte lin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Chick Embryo
Share to Histone Deacetylase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylases

Share to Oligodendroglia

Share to Rats, Inbred F344

Share to TCF Transcription Factors

Share to Transcription Factor 7-Like 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 19503085
DOI: 10.1038/nn.2333
PMCID: PMC2701973

Genes

HDAC1
HDAC2
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19503085-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction.PMID 19503085Read ↗

The Wnt effector TCF7l2 promotes oligodendroglial differentiation by repressing autocrine BMP4-mediated signalingSemantic proximity Read ↗

Epigenetic regulation of oligodendrocyte myelination in developmental disorders and neurodegenerative diseasesSemantic proximity Read ↗

Olig1 Acetylation and Nuclear Export Mediate Oligodendrocyte Development.Semantic proximity Read ↗

Antagonistic regulation of PAF1C and p-TEFb is required for oligodendrocyte differentiation.Semantic proximity Read ↗

Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalonSemantic proximity Read ↗

HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells.Semantic proximity Read ↗

Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltrationSemantic proximity Read ↗

Brg1 directly regulates Olig2 transcription and is required for oligodendrocyte progenitor cell specificationSemantic proximity Read ↗

CIC is a Critical Regulator of Neuronal DifferentiationSemantic proximity Read ↗

Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8Semantic proximity Read ↗

Overexpression of OLIG2 and MYT1L Transcription Factors Enhance the Differentiation Potential of Human Mesenchymal Stem Cells into OligodendrocytesSemantic proximity Read ↗

The INO80 chromatin remodeling complex regulates histone H2A.Z mobility and the G1-S transition in oligodendrocyte precursorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.