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Article

STAG2 promotes the myelination transcriptional program in oligodendrocytes.

eLife - 12 Aug 2022

Cheng Ningyan, Li Guanchen, Kanchwala Mohammed, Evers Bret M, Xing Chao, Yu Hongtao

Abstract excerpt

Cohesin folds chromosomes via DNA loop extrusion. Cohesin-mediated chromosome loops regulate transcription by shaping long-range enhancer-promoter interactions, among other mechanisms. Mutations of cohesin subunits and regulators cause human developmental diseases termed cohesinopathy. Vertebrate cohesin consists of SMC1, SMC3, RAD21, and either STAG1 or STAG2. To probe the physiological functions of cohesin, we...

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Identifiers

PMID: 35959892
DOI: 10.7554/eLife.77848
PMCID: PMC9439679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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