Article
Tead1 regulates the expression of Peripheral Myelin Protein 22 during Schwann cell development.
Human molecular genetics - 15 Jul 2016
Lopez-Anido Camila, Poitelon Yannick, Gopinath Chetna, Moran John J, Ma Ki Hwan, Law William D, Antonellis Anthony, Feltri M Laura, Svaren John
Abstract excerpt
Schwann cells are myelinating glia in the peripheral nervous system that form the myelin sheath. A major cause of peripheral neuropathy is a copy number variant involving the Peripheral Myelin Protein 22 (PMP22) gene, which is located within a 1.4-Mb duplication on chromosome 17 associated with the most common form of Charcot-Marie-Tooth Disease (CMT1A). Rodent models of CMT1A have been used to show that reducing...
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