Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage.

The Journal of cell biology - 17 May 2010

Finzsch Markus, Schreiner Silke, Kichko Tatjana, Reeh Peter, Tamm Ernst R, Bösl Michael R, Meijer Dies, Wegner Michael

Abstract excerpt

Mutations in the transcription factor SOX10 cause neurocristopathies, including Waardenburg-Hirschsprung syndrome and peripheral neuropathies in humans. This is partly attributed to a requirement for Sox10 in early neural crest for survival, maintenance of pluripotency, and specification to sever...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Cell Lineage
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Peripheral Nervous System Diseases

Share to Schwann Cells

Share to SOXE Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 20457761
DOI: 10.1083/jcb.200912142
PMCID: PMC2872908

Genes

SOX10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20457761-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage.PMID 20457761Read ↗

<i>Sox10</i> is required for Schwann‐cell homeostasis and myelin maintenance in the adult peripheral nerveSemantic proximity Read ↗

Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10.Semantic proximity Read ↗

Myelin deficiencies in both the central and the peripheral nervous systems associated with a SOX10 mutation.Semantic proximity Read ↗

Congenital hypomyelinating neuropathy, central dysmyelination, and Waardenburg-Hirschsprung disease: phenotypes linked by SOX10 mutation.Semantic proximity Read ↗

Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages.Semantic proximity Read ↗

SOX10: 20 years of phenotypic plurality and current understanding of its developmental function.Semantic proximity Read ↗

Peripheral neuropathy with hypomyelination, chronic intestinal pseudo-obstruction and deafness: a developmental "neural crest syndrome" related to a SOX10 mutation.Semantic proximity Read ↗

Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs.Semantic proximity Read ↗

The importance of having your SOX on: role of SOX10 in the development of neural crest-derived melanocytes and glia.Semantic proximity Read ↗

The role of SOX10 during enteric nervous system development.Semantic proximity Read ↗

Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells.Semantic proximity Read ↗

Sox4 participates in the modulation of Schwann cell myelination.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.