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Article

Multiple origins of Plasmodium falciparum dihydropteroate synthetase mutant alleles associated with sulfadoxine resistance in India.

Antimicrobial agents and chemotherapy - 1 Jun 2011

Lumb Vanshika, Das Manoj K, Singh Neeru, Dev Vas, Khan Wajihullah, Sharma Yagya D

Abstract excerpt

With the spread of chloroquine (CQ)-resistant malaria in India, sulfadoxine-pyrimethamine (SP) alone or in combination with artesunate is used as an alternative antimalarial drug. Due to continuous drug pressure, the Plasmodium falciparum parasite is exhibiting resistance to antifolates because of mutations in candidate genes dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhps). Our earlier study...

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Identifiers

PMID: 21422213
DOI: 10.1128/AAC.01151-10
PMCID: PMC3101454

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