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Article

Plasmodium falciparum isolates in India exhibit a progressive increase in mutations associated with sulfadoxine-pyrimethamine resistance.

Antimicrobial agents and chemotherapy - 1 Mar 2004

Ahmed Anwar, Bararia Deepak, Vinayak Sumiti, Yameen Mohammed, Biswas Sukla, Dev Vas, Kumar Ashwani, Ansari Musharraf A, Sharma Yagya D

Abstract excerpt

The combination of sulfadoxine-pyrimethamine (SP) is used as a second line of therapy for the treatment of uncomplicated chloroquine-resistant Plasmodium falciparum malaria. Resistance to SP arises due to certain point mutations in the genes for the dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) enzymes of the parasite. We have analyzed these mutations in 312 field isolates of P. falciparum...

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Source

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Identifiers

PMID: 14982779
DOI: 10.1128/AAC.48.3.879-889.2004
PMCID: PMC353157

Genes

DHFR
DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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