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Article

Assessment of the origins and spread of putative resistance-conferring mutations in Plasmodium vivax dihydropteroate synthase.

The American journal of tropical medicine and hygiene - 1 Aug 2009

Hawkins Vivian N, Suzuki Stephanie M, Rungsihirunrat Kanchana, Hapuarachchi Hapuarachchige C, Maestre Amanda, Na-Bangchang Kesara, Sibley Carol Hopkins

Abstract excerpt

Infection with Plasmodium vivax is usually treated with chloroquine, but parasites are often exposed inadvertently to sulfadoxine-pyrimethamine. To infer patterns of selection and spread of resistant parasites in natural populations, we determined haplotypes of P. vivax dihydropteroate synthase ( dhps ) alleles that could confer resistance to sulfadoxine. We amplified the P. vivax pyrophosphokinase ( pppk )- dhps...

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PMID: 19635897

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