Article
Differential genetic hitchhiking around mutant pfcrt alleles in the Indian Plasmodium falciparum population.
The Journal of antimicrobial chemotherapy - 1 Mar 2012
Lumb Vanshika, Madan Rahul, Das Manoj K, Rawat Vipin, Dev Vas, Khan Wajihullah, Khan Haris, Sharma Yagya D
Abstract excerpt
OBJECTIVES: To study the origin and spread of the chloroquine-resistant Plasmodium falciparum population in the Indian subcontinent. METHODS: Fourteen microsatellites spanning a ∼120 kb region, flanking the P. falciparum chloroquine resistance transporter (pfcrt) gene, were analysed in 185 parasite isolates. RESULTS: The Indian P. falciparum population exhibited a selective valley of reduced genetic variation in...
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