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Article

Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase.

Malaria journal - 28 Apr 2008

Hawkins Vivian N, Auliff Alyson, Prajapati Surendra Kumar, Rungsihirunrat Kanchana, Hapuarachchi Hapuarachchige C, Maestre Amanda, O'Neil Michael T, Cheng Qin, Joshi Hema, Na-Bangchang Kesara, Sibley Carol Hopkins

Abstract excerpt

BACKGROUND: In order to maximize the useful therapeutic life of antimalarial drugs, it is crucial to understand the mechanisms by which parasites resistant to antimalarial drugs are selected and spread in natural populations. Recent work has demonstrated that pyrimethamine-resistance conferring mutations in Plasmodium falciparum dihydrofolate reductase (dhfr) have arisen rarely de novo, but spread widely in Asia...

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Identifiers

PMID: 18442404
DOI: 10.1186/1475-2875-7-72
PMCID: PMC2383903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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