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Article

TGF-β signaling plays an essential role in the growth and maintenance of intervertebral disc tissue

21 Mar 2011

Abstract excerpt

TGF-β signaling plays a critical role in cartilage and spine tissue development at embryonic stage but its role in postnatal intervertebral disc (IVD) tissue growth and maintenance remain poorly understood. In the present studies, we have deleted the Tgfbr2 gene in inner annulus fibrosus cells of the disc tissue and surrounding growth plate chondrocytes using Col2a1-CreER(T2) transgenic mice. We found that TGF-β...

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PMID: 21420963
DOI: 10.1016/j.febslet.2011.03.034

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