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TGF‐β1 Inhibits Osteoclast Differentiation and Abnormal Angiogenesis in Intervertebral Disc Degeneration: Evidence from RNA Sequencing and Animal Studies

28 Nov 2023

Abstract excerpt

OBJECTIVE: Mechanisms involved in developing intervertebral disc degeneration (IDD) are poorly understood, thus making developing effective therapies difficult. This study aimed to suggest a possible molecular mechanism, based on transcriptome sequencing-identified transforming growth factor (TGF-β), underlying the effects on bone homeostasis in IDD. METHODS: A mouse model for IDD was established. Transcriptome...

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Share to Cervical and Thoracic Myelopathy
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PMID: 38014468
DOI: 10.1111/os.13912

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