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Article

Genetic Analysis of the Mammalian Transforming Growth Factor-β Superfamily

1 Dec 2002

Abstract excerpt

Members of the TGF-beta superfamily, which includes TGF-betas, growth differentiation factors, bone morphogenetic proteins, activins, inhibins, and glial cell line-derived neurotrophic factor, are synthesized as prepropeptide precursors and then processed and secreted as homodimers or heterodimers. Most ligands of the family signal through transmembrane serine/threonine kinase receptors and SMAD proteins to...

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PMID: 12466190
DOI: 10.1210/er.2002-0003

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