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Article

Transforming growth factor <i>Beta2</i> is required for valve remodeling during heart development

20 Jul 2011

Abstract excerpt

Although the function of transforming growth factor beta2 (TGFβ2) in epithelial mesenchymal transition (EMT) is well studied, its role in valve remodeling remains to be fully explored. Here, we used histological, morphometric, immunohistochemical and molecular approaches and showed that significant dysregulation of major extracellular matrix (ECM) components contributed to valve remodeling defects in Tgfb2(-/-)...

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PMID: 21780244
DOI: 10.1002/dvdy.22702

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