Article
Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice.
Arthritis and rheumatism - 1 Dec 2013
Shen Jie, Li Jia, Wang Baoli, Jin Hongting, Wang Meina, Zhang Yejia, Yang Yunzhi, Im Hee-Jeong, O'Keefe Regis, Chen Di
Abstract excerpt
OBJECTIVE: While transforming growth factor β (TGFβ) signaling plays a critical role in chondrocyte metabolism, the TGFβ signaling pathways and target genes involved in cartilage homeostasis and the development of osteoarthritis (OA) remain unclear. Using an in vitro cell culture method and an in vivo mouse genetic approach, we undertook this study to investigate TGFβ signaling in chondrocytes and to determine...
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