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Article

Molecular profiling of the developing mouse axial skeleton: a role for Tgfbr2 in the development of the intervertebral disc

9 Mar 2010

Abstract excerpt

BACKGROUND: Very little is known about how intervertebral disc (IVD) is formed or maintained. Members of the TGF-beta superfamily are secreted signaling proteins that regulate many aspects of development including cellular differentiation. We recently showed that deletion of Tgfbr2 in Col2a expressing mouse tissue results in alterations in development of IVD annulus fibrosus. The results suggested TGF-beta has an...

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Share to Cervical and Thoracic Myelopathy
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PMID: 20214815
DOI: 10.1186/1471-213x-10-29

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