Article

The sodium leak channel NALCN is regulated by neuronal SNARE complex proteins

2024-09-03

Abstract excerpt

The sodium leak channel NALCN is vital for the regulation of electrical activity in neurons and other excitable cells, and mutations in the channel or its auxiliary proteins lead to severe neurodevelopmental disorders. Here we show that the neuronal SNARE complex proteins syntaxin and SNAP25, which enable synaptic transmission in the nervous system, inhibit the activity of the NALCN channel complex in both heterol...

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Literature Corpus work: 843d7af9-253c-5a10-814e-3fcfa1fca182
DOI: 10.1101/2024.09.03.610923

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