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Article

Evidence for a radial SNARE super-complex mediating neurotransmitter release at the Drosophila neuromuscular junction.

Journal of cell science - 15 Jul 2013

Megighian Aram, Zordan Mauro, Pantano Sergio, Scorzeto Michele, Rigoni Michela, Zanini Damiano, Rossetto Ornella, Montecucco Cesare

Abstract excerpt

The SNARE proteins VAMP/synaptobrevin, SNAP-25 and syntaxin are core components of the apparatus that mediates neurotransmitter release. They form a heterotrimeric complex, and an undetermined number of SNARE complexes assemble to form a super-complex. Here, we present a radial model of this nanomachine. Experiments performed with botulinum neurotoxins led to the identification of one arginine residue in SNAP-25...

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Identifiers

PMID: 23687382
DOI: 10.1242/jcs.123802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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