Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations of Single Residues in the Complexin N-terminus Exhibit Distinct Phenotypes in Synaptic Vesicle Fusion.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 Jul 2024

Toulme Estelle, Murach Jacqueline, Bärfuss Simon, Kroll Jana, Malsam Jörg, Trimbuch Thorsten, Herman Melissa A, Söllner Thomas H, Rosenmund Christian

Abstract excerpt

The release of neurotransmitters (NTs) at central synapses is dependent on a cascade of protein interactions, specific to the presynaptic compartment. Among those dedicated molecules, the cytosolic complexins play an incompletely defined role as synaptic transmission regulators. Complexins are multidomain proteins that bind soluble N-ethylmaleimide sensitive factor attachment protein receptor complexes,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Vesicular Transport
Share to Exocytosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Fusion

Share to Mice, Inbred C57BL

Share to Nerve Tissue Proteins

Share to Neurons

Share to Synaptic Transmission

Share to Synaptic Vesicles

Source

Open in PubMed Open full text

Identifiers

PMID: 38951039
DOI: 10.1523/JNEUROSCI.0076-24.2024
PMCID: PMC11293444

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations of Single Residues in the Complexin N-terminus Exhibit Distinct Phenotypes in Synaptic Vesicle Fusion.PMID 38951039Read ↗

Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.Semantic proximity Read ↗

Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes.Semantic proximity Read ↗

Molecular mechanisms of COMPLEXIN fusion clamp function in synaptic exocytosis revealed in a new Drosophila mutant.Semantic proximity Read ↗

Complexin has opposite effects on two modes of synaptic vesicle fusion.Semantic proximity Read ↗

Interaction of the Complexin Accessory Helix with Synaptobrevin Regulates Spontaneous Fusion.Semantic proximity Read ↗

The Dual Function of the Polybasic Juxtamembrane Region of Syntaxin 1A in Clamping Spontaneous Release and Stimulating Ca2+-Triggered Release in Neuroendocrine Cells.Semantic proximity Read ↗

Complexins living up to their name--new light on their role in exocytosis.Semantic proximity Read ↗

Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis.Semantic proximity Read ↗

The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis.Semantic proximity Read ↗

A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis.Semantic proximity Read ↗

Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening.Semantic proximity Read ↗

Structural determinants of synaptobrevin 2 function in synaptic vesicle fusion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.