Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission.

doi:10.1016/0092-8674(95)90414-x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission.

Cell - 27 Jan 1995

Schulze K L, Broadie K, Perin M S, Bellen H J

Abstract excerpt

Cloning and characterization of the Drosophila syntaxin-1A gene, syx-1A, reveal that it is present in several tissues but is predominantly expressed in the nervous system, where it is localized to axons and synapses. We have generated an allelic series of loss-of-function mutations that result in embryonic lethality with associated morphological and secretory defects dependent on the severity of the mutant...

Topics

Alleles
Amino Acid Sequence
Animals
Antigens, Surface
Conserved Sequence
Drosophila
Electrophysiology
Evoked Potentials
Genes, Lethal
Membrane Proteins
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis

Nerve Tissue Proteins

Nervous System Physiological Phenomena

Neuromuscular Junction

Polymerase Chain Reaction

RNA, Messenger

Sequence Homology, Amino Acid

Source

Open in PubMed

Identifiers

PMID: 7834751
DOI: 10.1016/0092-8674(95)90414-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7834751-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission.PMID 7834751Read ↗

Targeted mutations in the syntaxin H3 domain specifically disrupt SNARE complex function in synaptic transmission.Semantic proximity Read ↗

Drosophila syntaxin is required for cell viability and may function in membrane formation and stabilization.Semantic proximity Read ↗

Overexpression of cysteine-string proteins in Drosophila reveals interactions with syntaxin.Semantic proximity Read ↗

Analysis of conditional heterozygous STXBP1 mutations in human neurons.Semantic proximity Read ↗

The non-neuronal syntaxin SYN-1 regulates defecation behavior and neural activity in C. elegans through interaction with the Munc13-like protein AEX-1.Semantic proximity Read ↗

The sodium leak channel NALCN is regulated by neuronal SNARE complex proteinsSemantic proximity Read ↗

Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions.Semantic proximity Read ↗

The Caenorhabditis elegans unc-64 locus encodes a syntaxin that interacts genetically with synaptobrevin.Semantic proximity Read ↗

Syntaxin requirement for Ca2+-triggered exocytosis in neurons and endocrine cells demonstrated with an engineered neurotoxin.Semantic proximity Read ↗

Differential expression of syntaxin 1A and 1B by noradrenergic and adrenergic chromaffin cells.Semantic proximity Read ↗

SLO-1 potassium channels control quantal content of neurotransmitter release at the C. elegans neuromuscular junction.Semantic proximity Read ↗

Syntaxin 3B: A SNARE Protein Required for Vision.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.