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Article

Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics.

Journal of psychiatric research - 1 Aug 2012

Schuhmacher Anna, Becker Tim, Rujescu Dan, Quednow Boris B, Lennertz Leonhard, Wagner Michael, Benninghoff Jens, Rietschel Marcella, Häfner Heinz, Franke Petra, Wölwer Wolfgang, Gaebel Wolfgang, Maier Wolfgang, Mössner Rainald

Abstract excerpt

Serotonergic transmission is considered relevant in the pathophysiology and the treatment of schizophrenia. Tryptophan hydroxylase (TPH) is the rate limiting enzyme in the biosynthesis of serotonin. While the TPH1 gene has been found to be associated with schizophrenia, studies focusing on TPH2 variants did not yield conclusive results for schizophrenia or the response to antipsychotic medication. We analyzed...

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Source

Identifiers

PMID: 22655589
DOI: 10.1016/j.jpsychires.2012.04.021

Genes

TPH2
TPH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics.PMID 22655589Read ↗

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