Article
Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2011
Gordon Scott M, Carty Shannon A, Kim Jiyeon S, Zou Tao, Smith-Garvin Jennifer, Alonzo Eric S, Haimm Ethan, Sant'Angelo Derek B, Koretzky Gary A, Reiner Steven L, Jordan Martha S
Abstract excerpt
Conventional and nonconventional T cell development occur in the thymus. Nonconventional thymocytes that bear characteristics typically associated with innate immune cells are termed innate-like lymphocytes (ILLs). Mice harboring a tyrosine to phenylalanine mutation in the adaptor protein Src homology 2 domain-containing leukocyte protein of 76 kDa at residue 145 (Y145F mice) develop an expanded population of...
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