Article

Embryonic lymphocytes contribute to a genetic form of autoimmune inflammation

2023-11-24

Abstract excerpt

Omenn Syndrome (OS) is a rare hematological disorder, caused by hypomorphic mutations in genes involved in B-/T-cell receptor (BCR/TCR) rearrangement that result in impaired lymphocyte development and immunodeficiency. Notwithstanding, few T-cell clones enriched in self-reactive specificities expand in peripheral tissues, where they trigger severe inflammation and autoimmune reactions. Interestingly, residual OS l...

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Literature Corpus work: e8a0cbcc-d1d5-51a1-b721-a8f06ed8fddd
DOI: 10.1101/2023.11.24.568475

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