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Article

MHC class II-restricted interaction between thymocytes plays an essential role in the production of innate CD8+ T cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2011

Min Hye Sook, Lee You Jeong, Jeon Yoon Kyung, Kim Eun Ji, Kang Byung Hyun, Jung Kyeong Cheon, Chang Cheong-Hee, Park Seong Hoe

Abstract excerpt

We have recently shown that MHC class II-dependent thymocyte-thymocyte (T-T) interaction successfully generates CD4(+) T cells (T-T CD4(+) T cells), and that T-T CD4(+) T cells expressing promyelocytic leukemia zinc finger protein (PLZF) show an innate property both in mice and humans. In this article, we report that the thymic T-T interaction is essential for the conversion of CD8(+) T cells into innate...

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Identifiers

PMID: 21478404
DOI: 10.4049/jimmunol.1002825
PMCID: PMC3192403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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