Article
Thymic low affinity/avidity interaction selects natural Th1 cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2015
Kang Byung Hyun, Park Hyo Jin, Yum Hye In, Park Seung Pyo, Park Jin Kyun, Kang Eun Ha, Lee Jae-Il, Lee Eun Bong, Park Chung-Gyu, Jung Kyeong Cheon, Park Seong Hoe
Abstract excerpt
Identification of intrathymic eomesodermin(+) (Eomes(+)) CD4 T cells creates a novel idea that there is more than one way for the generation of innate CD4 T cells. Promyelocytic leukemia zinc finger protein(+) T cells and natural Th17 cells are known to be generated by sensing a high and persistent TCR strength, whereas this is not the case for Eomes(+) CD4 T cells. These cells go through low-level signal during...
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