Article

EOMES and IL-10 regulate anti-tumor activity of PD-1 <sup>+</sup> CD4 <sup>+</sup> T-cells in B-cell Non-Hodgkin lymphoma

2020-03-09

Abstract excerpt

The transcription factor Eomesodermin (EOMES) promotes IL-10 production of CD4 + T-cells, which has been linked to immunosuppressive and cytotoxic activities. We detected EOMES-expressing CD4 + T-cells in lymph node samples of patients with chronic lymphocytic leukemia (CLL) or diffuse large B-cell lymphoma. This was in line with an observed expansion of EOMES-positive CD4 + T-cells in leukemic Eµ-TCL1 mice, a...

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Literature Corpus work: bd77cf83-1626-58ea-a657-bf90e664cdac
DOI: 10.1101/2020.03.09.983098

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EOMES and IL-10 regulate anti-tumor activity of PD-1 <sup>+</sup> CD4 <sup>+</sup> T-cells in B-cell Non-Hodgkin lymphomaDOI 10.1101/2020.03.09.983098Read

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