Article
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin.
Nature immunology - 1 Dec 2005
Intlekofer Andrew M, Takemoto Naofumi, Wherry E John, Longworth Sarah A, Northrup John T, Palanivel Vikram R, Mullen Alan C, Gasink Christopher R, Kaech Susan M, Miller Joseph D, Gapin Laurent, Ryan Kenneth, Russ Andreas P, Lindsten Tullia, Orange Jordan S, Goldrath Ananda W, Ahmed Rafi, Reiner Steven L
Abstract excerpt
Two seemingly unrelated hallmarks of memory CD8(+) T cells are cytokine-driven proliferative renewal after pathogen clearance and a latent effector program in anticipation of rechallenge. Memory CD8(+) T cells and natural killer cells share cytotoxic potential and dependence on the growth factor interleukin 15. We now show that mice with compound mutations of the genes encoding the transcription factors T-bet and...
Topics
- Animals
- CD8-Positive T-Lymphocytes
- Cells, Cultured
- Humans
- Immunologic Memory
- Interleukin-15
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic