Article
Culture-differentiated CD8(+) T cells acquire innate memory-like traits and respond to a pathogen-associated molecule.
Immunology and cell biology - 1 Apr 2014
Biswas Ratna, Mukherjee Subhadeep, Sinha Debolina, Ghosh Amlan Kanti, Biswas Tapas
Abstract excerpt
Selection of conventional CD4(+) or CD8(+) T cells is usually driven by the interaction of double-positive CD4(+)CD8(+) thymocytes with epithelial cells. Here, we demonstrate preferential selection of CD8(+) thymocytes from in vitro differentiation of CD4(+)CD8(+) double-positive thymocytes exhibiting the characteristics of nonconventional innate memory CD8(+) cells. In contrast to conventional CD8(+) thymocytes,...
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