Article
Copy number variation and selection during reprogramming to pluripotency.
Nature - 3 Mar 2011
Hussein Samer M, Batada Nizar N, Vuoristo Sanna, Ching Reagan W, Autio Reija, Närvä Elisa, Ng Siemon, Sourour Michel, Hämäläinen Riikka, Olsson Cia, Lundin Karolina, Mikkola Milla, Trokovic Ras, Peitz Michael, Brüstle Oliver, Bazett-Jones David P, Alitalo Kari, Lahesmaa Riitta, Nagy Andras, Otonkoski Timo
Abstract excerpt
The mechanisms underlying the low efficiency of reprogramming somatic cells into induced pluripotent stem (iPS) cells are poorly understood. There is a clear need to study whether the reprogramming process itself compromises genomic integrity and, through this, the efficiency of iPS cell establishment. Using a high-resolution single nucleotide polymorphism array, we compared copy number variations (CNVs) of...
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