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Article

Embryonic stem cell potency fluctuates with endogenous retrovirus activity.

Nature - 5 Jul 2012

Macfarlan Todd S, Gifford Wesley D, Driscoll Shawn, Lettieri Karen, Rowe Helen M, Bonanomi Dario, Firth Amy, Singer Oded, Trono Didier, Pfaff Samuel L

Abstract excerpt

Embryonic stem (ES) cells are derived from blastocyst-stage embryos and are thought to be functionally equivalent to the inner cell mass, which lacks the ability to produce all extraembryonic tissues. Here we identify a rare transient cell population within mouse ES and induced pluripotent stem (iPS) cell cultures that expresses high levels of transcripts found in two-cell (2C) embryos in which the blastomeres...

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Identifiers

PMID: 22722858
DOI: 10.1038/nature11244
PMCID: PMC3395470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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