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Article

Unique features of mutations revealed by sequentially reprogrammed induced pluripotent stem cells.

Nature communications - 18 Feb 2015

Gao Shuai, Zheng Caihong, Chang Gang, Liu Wenqiang, Kou Xiaochen, Tan Kun, Tao Li, Xu Kai, Wang Hong, Cai Jun, Tian Jianhui, Gao Shaorong

Abstract excerpt

Although viable mice can be generated from induced pluripotent stem cells (iPSCs), the impact of accumulated mutations on the developmental potential of the resulting iPSCs remains to be determined. Here, we demonstrate that all-iPSC mice generated through tetraploid blastocysts complementation can tolerate the accumulation of somatic mutations for up to six generations using a Tet-on inducible reprogramming...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25692725
DOI: 10.1038/ncomms7318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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