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Article

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.

Nature - 17 Mar 2011

Oberst Andrew, Dillon Christopher P, Weinlich Ricardo, McCormick Laura L, Fitzgerald Patrick, Pop Cristina, Hakem Razq, Salvesen Guy S, Green Douglas R

Abstract excerpt

Caspase-8 has two opposing biological functions--it promotes cell death by triggering the extrinsic pathway of apoptosis, but also has a survival activity, as it is required for embryonic development, T-lymphocyte activation, and resistance to necrosis induced by tumour necrosis factor-α (TNF-α) and related family ligands. Here we show that development of caspase-8-deficient mice is completely rescued by ablation...

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Source

Open in PubMed Open full text

Identifiers

PMID: 21368763
DOI: 10.1038/nature09852
PMCID: PMC3077893

Genes

RIPK3
CFLAR
FAS
FASLG
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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