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Article

Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 9 Feb 2016

Ram Daniel R, Ilyukha Vladimir, Volkova Tatyana, Buzdin Anton, Tai Albert, Smirnova Irina, Poltorak Alexander

Abstract excerpt

cFLIP, an inhibitor of apoptosis, is a crucial regulator of cellular death by apoptosis and necroptosis; its importance in development is exemplified by the embryonic lethality in cFLIP-deficient animals. A homolog of caspase 8 (CASP8), cFLIP exists in two main isoforms: cFLIPL (long) and cFLIPR (short). Although both splice variants regulate death receptor (DR)-induced apoptosis by CASP8, the specific role of...

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Source

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Identifiers

PMID: 26798068
DOI: 10.1073/pnas.1517562113
PMCID: PMC4760830

Genes

CASP8
FADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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