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Article

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity.

Genes & development - 1 Apr 2003

Salmena Leonardo, Lemmers Benedicte, Hakem Anne, Matysiak-Zablocki Elzbieta, Murakami Kiichi, Au P Y Billie, Berry Donna M, Tamblyn Laura, Shehabeldin Amro, Migon Eva, Wakeham Andrew, Bouchard Denis, Yeh Wen Chen, McGlade Jane C, Ohashi Pamela S, Hakem Razqallah

Abstract excerpt

Defects in death receptor-mediated apoptosis have been linked to cancer and autoimmune disease in humans. The in vivo role of caspase 8, a component of this pathway, has eluded analysis in postnatal tissues because of the lack of an appropriate animal model. Targeted disruption of caspase 8 is lethal in utero. We generated mice with a targeted caspase 8 mutation that is restricted to the T-cell lineage. Despite...

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Identifiers

PMID: 12654726
DOI: 10.1101/gad.1063703
PMCID: PMC196031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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