Article
Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America - 5 Sept 2006
Wang Danling, Qian Li, Xiong Hui, Liu Jiandong, Neckameyer Wendi S, Oldham Sean, Xia Kun, Wang Jianzhi, Bodmer Rolf, Zhang Zhuohua
Abstract excerpt
Parkinson's disease (PD) is the most frequent neurodegenerative movement disorder. Mutations in the PINK1 gene are linked to the autosomal recessive early onset familial form of PD. The physiological function of PINK1 and pathological abnormality of PD-associated PINK1 mutants are largely unknown. We here show that inactivation of Drosophila PINK1 (dPINK1) using RNAi results in progressive loss of dopaminergic...
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