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Article

Antagonism of proteasome inhibitor-induced heme oxygenase-1 expression by PINK1 mutation.

PloS one - 1 Jan 2017

Sheng Xiang-Jun, Tu Hunag-Ju, Chien Wei-Lin, Kang Kai-Hsiang, Lu Dai-Hua, Liou Horng-Huei, Lee Ming-Jen, Fu Wen-Mei

Abstract excerpt

PTEN-induced putative kinase 1 (PINK1) is an integral protein in the mitochondrial membrane and maintains mitochondrial fidelity. Pathogenic mutations in PINK1 have been identified as a cause of early-onset autosomal recessive familial Parkinson's disease (PD). The ubiquitin proteasome pathway is associated with neurodegenerative diseases. In this study, we investigated whether mutations of PINK1 affects the...

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Source

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Identifiers

PMID: 28806787
DOI: 10.1371/journal.pone.0183076
PMCID: PMC5555616

Genes

PINK1
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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