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Article

DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway

26 Jan 2010

Abstract excerpt

Loss-of-function DJ-1 (PARK7) mutations have been linked with a familial form of early onset Parkinson disease. Numerous studies have supported the role of DJ-1 in neuronal survival and function. Our initial studies using DJ-1-deficient neurons indicated that DJ-1 specifically protects the neurons against the damage induced by oxidative injury in multiple neuronal types and degenerative experimental paradigms,...

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PMID: 20133695
DOI: 10.1073/pnas.0914876107

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Related research

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DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathwayPMID 20133695Read ↗

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DJ-1 modulates the expression of Cu/Zn-superoxide dismutase-1 through the Erk1/2-Elk1 pathway in neuroprotection.Semantic proximity Read ↗

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Inactivation of <i>Drosophila</i> DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signalingSemantic proximity Read ↗

Parkinson disease-associated protein DJ-1 regulates the autophagic-lysosomal pathway through ROS-dependent modulation of the AMPK/mTORC1 axisSemantic proximity Read ↗

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