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Article

PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons.

Biochimica et biophysica acta - 1 Jun 2011

Wang Hung-Li, Chou An-Hsun, Wu Ai-Shun, Chen Si-Ying, Weng Yi-Hsin, Kao Yu-Cheng, Yeh Tu-Hsueh, Chu Po-Ju, Lu Chin-Song

Abstract excerpt

Mutations in PTEN-induced kinase 1 (PINK1) gene cause recessive familial type 6 of Parkinson's disease (PARK6). PINK1 is believed to exert neuroprotective effect on SN dopaminergic cells by acting as a mitochondrial Ser/Thr protein kinase. Autosomal recessive inheritance indicates the involvement of loss of PINK1 function in PARK6 pathogenesis. In the present study, confocal imaging of cultured SN dopaminergic...

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Source

Identifiers

PMID: 21421046
DOI: 10.1016/j.bbadis.2011.03.007

Genes

PINK1
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons.PMID 21421046Read ↗

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R492X mutation in PTEN-induced putative kinase 1 induced cellular mitochondrial dysfunction and oxidative stress.Semantic proximity Read ↗

Chronic treatment with the complex I inhibitor MPP+ depletes endogenous PTEN-induced kinase 1 (PINK1) via up-regulation of Bcl-2–associated athanogene 6 (BAG6)Semantic proximity Read ↗

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