Increase of oxidative stress by a novel PINK1 mutation, P209A.

Abstract excerpt

Mutation in the human PTEN-induced protein kinase 1 (PINK1) gene is responsible for the second most common form of recessive Parkinson disease (PD). We have identified a single heterozygous PINK1 mutation, P209A, from a cohort of 68 patients with early onset PD. From age 31, this patient developed an asymmetric bradykinesia with rigidity that was L-DOPA responsive. An [(18)F]-fluorodopa PET scan showed reduced...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Age of Onset
• Share to Heme Oxygenase-1
• Share to Levodopa