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Article

Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis.

Human molecular genetics - 15 Aug 2004

Jiang Houbo, Ren Yong, Zhao Jinghui, Feng Jian

Abstract excerpt

Parkinson's disease (PD) is characterized by the selective degeneration of dopaminergic (DA) neurons in substantia nigra pars compacta (SNpc). A combination of genetic and environmental factors contributes to such a specific loss. Among the five PD-linked genes identified so far, parkin, a protein-ubiquitin E3 ligase, appears to be the most prevalent genetic factor in PD. Although a variety of substrates have...

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Identifiers

PMID: 15198987
DOI: 10.1093/hmg/ddh180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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