Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons.

Free radical biology & medicine - 1 Mar 2014

Zhou Zhi Dong, Refai Fathima Shaffra, Xie Shao Ping, Ng Shin Hui, Chan Christine Hui Shan, Ho Patrick Ghim Hoe, Zhang Xiao Dong, Lim Tit Meng, Tan Eng King

Abstract excerpt

PINK1 mutations cause autosomal recessive forms of Parkinson disease (PD). Previous studies suggest that the neuroprotective function of wild-type (WT) PINK1 is related to mitochondrial homeostasis. PINK1 can also localize to the cytosol; however, the cytosolic function of PINK1 has not been full...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dopamine
Share to Dopaminergic Neurons
Share to Free Radicals

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrogen Peroxide

Share to Oxidative Stress

Share to Parkinson Disease

Share to Protein Kinases

Share to Tyrosine 3-Monooxygenase

Source

Identifiers

PMID: 24374372
DOI: 10.1016/j.freeradbiomed.2013.12.015

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24374372-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons.PMID 24374372Read ↗

PINK1 function in health and disease.Semantic proximity Read ↗

Molecular mechanisms of PINK1-related neurodegeneration.Semantic proximity Read ↗

Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.Semantic proximity Read ↗

A subcellular analysis of genetic modulation of PINK1 on mitochondrial alterations, autophagy and cell death.Semantic proximity Read ↗

PINK1 Regulates Dopamine and Lipids at Mitochondria to Maintain Synapses and Neuronal FunctionSemantic proximity Read ↗

Mitochondrial-Dependent and Independent Functions of PINK1Semantic proximity Read ↗

Silencing of PINK1 Expression Affects Mitochondrial DNA and Oxidative Phosphorylation in DOPAMINERGIC CellsSemantic proximity Read ↗

The impact of reactive oxygen species and genetic mitochondrial mutations in Parkinson's disease.Semantic proximity Read ↗

Mitochondrial morphogenesis, distribution, and Parkinson disease: insights from PINK1.Semantic proximity Read ↗

Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson's disease triggered by mitochondrial stressSemantic proximity Read ↗

PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neurons.Semantic proximity Read ↗

Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.