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Article

Mechanisms for stalled replication fork stabilization: new targets for synthetic lethality strategies in cancer treatments.

EMBO reports - 1 Sept 2018

Liao Hongwei, Ji Fang, Helleday Thomas, Ying Songmin

Abstract excerpt

Timely and faithful duplication of the entire genome depends on completion of replication. Replication forks frequently encounter obstacles that may cause genotoxic fork stalling. Nevertheless, failure to complete replication rarely occurs under normal conditions, which is attributed to an intricate network of proteins that serves to stabilize, repair and restart stalled forks. Indeed, many of the components in...

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Identifiers

PMID: 30108055
DOI: 10.15252/embr.201846263
PMCID: PMC6123652

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