Article
Nerve growth factor β polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment.
The pharmacogenomics journal - 1 Aug 2012
Levran O, Peles E, Hamon S, Randesi M, Zhao C, Zhang B, Adelson M, Kreek M J
Abstract excerpt
Opioid addiction is a chronic disease with high genetic contribution and a large inter-individual variability in therapeutic response. The goal of this study was to identify pharmacodynamic factors that modulate methadone dose requirement. The neurotrophin family is involved in neural plasticity, learning, memory and behavior and deregulated neural plasticity may underlie the pathophysiology of drug addiction....
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