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Article

Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction.

Pharmacogenomics - 1 May 2013

Levran Orna, Peles Einat, Randesi Matthew, Shu Xu, Ott Jurg, Shen Pei-Hong, Adelson Miriam, Kreek Mary Jeanne

Abstract excerpt

AIM: The interindividual variability in the dose required for effective methadone maintenance treatment (MMT) for opioid addiction may be influenced in part by genetic variations in genes encoding pharmacodynamic factors of methadone. This study was conducted to identify some of these variants. MATERIALS & METHODS: This study focused on 11 genes encoding components of the opioidergic (OPRM1, POMC and ARRB2), the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23651024
DOI: 10.2217/pgs.13.58
PMCID: PMC3867202

Genes

DRD2
BDNF
NTRK2
OPRM1
ARRB2
GRIN1
NTRK1
POMC

Provenance

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